NCT06483815

Fungal Infections During and After the SARS-CoV-2 Pandemic: A Retrospective Comparison

Comparative Retrospective Analysis of Fungal Positivity Rates During and Post-SARS-CoV-2 Pandemic Periods

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 1,441 (estimated)
• Sponsor: Bekir Sami Uyanık · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

his study aims to retrospectively compare fungal positivity rates between the SARS-CoV-2 pandemic and the post-pandemic periods. During the pandemic, Candida species had a positivity rate of 17.36%, and Aspergillus had a rate of 2.22%. Post-pandemic, these rates decreased to 9.29% and 1.00%, respectively. The overall fungal positivity rate decreased from 9.15% during the pandemic to 5.13% post-pandemic. Statistical analysis revealed a significant decrease in fungal positivity rates post-pandemic (p \< 0.01). These findings underscore the effectiveness of post-pandemic healthcare interventions and infection control strategies.

Detailed description

The study aims to retrospectively compare fungal positivity rates by focusing on Candida and Aspergillus species during the SARS-CoV-2 pandemic and in the post-pandemic period. The dataset includes samples collected during the pandemic period (N=623) and the subsequent post-pandemic period (N=818). Fungal positivity rates were calculated and statistically analyzed using chi-square tests, and significance was determined as p\<0.01. During the SARS-CoV-2 pandemic, Candida species showed a positivity rate of 17.36%, while the rate in the post-pandemic period significantly decreased to 9.29% (p=0.002). In contrast, Aspergillus species did not show a significant change in positivity rates between the pandemic (2.22%) and post-pandemic (1.00%) periods (p=0.186, NS). Overall, the study provides valuable insights into the epidemiology of fungal infections during and after the SARS-CoV-2 pandemic, suggesting possible shifts in fungal pathogen prevalence and healthcare priorities. The findings contribute to the development of targeted healthcare strategies and surveillance measures for fungal infections in the post-pandemic era. Study Design: Retrospective comparative analysis Data Analysis: Chi-square tests, p\<0.01 considered significant

Conditions

• Fungal Infections

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Culture, İsolation	Data on patient demographics, clinical conditions, and fungal infection positivity rates were extracted from hospital records. Fungal positivity rates were calculated based on laboratory results and presented as percentages. Statistical analyses were performed using the Chi-Square test, and p-values were reported.

Timeline

• Start date: 2024-06-01
• Primary completion: 2024-07-20
• Completion: 2024-07-30
• First posted: 2024-07-03
• Last updated: 2024-07-05

Locations

1 site across 1 country: Turkey (Türkiye)