NCT06483542

Bionenergetic Balance During CVVH

A Retrospective Analysis of the Impact of Non-nutritional Calories During Continuous Veno-Venous Hemofiltration

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: All
• Age: 18 Years – 130 Years
• Healthy volunteers: Not accepted

Summary

The bioenergetic balance is the sum of energy exchanged during CRRT and is mostly defined by citrate glucose and lactate. When CRRT was performed with the older dialysis fluids, glucose and lactate could be an important source of energy next to citrate when used as predilution (6, 7). During continuous venovenous hemofiltration (CVVH), a subgroup of CRRT which is performed with the newer dialysis fluids without lactate or glucose as advocated by the KDIGOguidelines, glucose and in a minor way lactate mostly induce a loss of energy. The first aim is to determine how this bioenergetic balance impacts energy need compared to the measured energy with indirect calorimetry and how nutrition therapy needs to be adapted. Also, disease specific predicting equation have been created for patients suffering from acute kidney injury treated with renal replacement therapy. How this predicting equation and other existing predicting equations agree with the measured REE has not been validated yet. The second aim is to determine how predictive equations correlate with measured REE in patients treated with CVVH.

Conditions

• Acute Kidney Injury
• Continuous Venovenous Hemofiltration
• Energy Metabolism
• Resting Energy Expenditure
• Nutrition Therapy

Interventions

Type	Name	Description
OTHER	bioenergetic balance	Bioenergetic balance is calculated for all patients who had a resting energy expenditure measurement with indirect calorimetry.

Timeline

• Start date: 2023-02-01
• Primary completion: 2023-04-30
• Completion: 2024-09-30
• First posted: 2024-07-03
• Last updated: 2024-07-03

Locations

1 site across 1 country: Belgium