NCT06482970

Effectiveness of Exercise Plus Pain Neuroscience Education on Brain Function in Knee Osteoarthritis

Brain Function, Clinical and Psychosocial Outcomes After Neuromuscular Exercise Plus Pain Neuroscience Education Intervention in Patients With Chronic Pain Due to Knee Osteoarthritis. A Randomized Controlled Trial Protocol

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 57 (estimated)
• Sponsor: Universidad Santo Tomas, Chile · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

A three-arm randomized controlled trial will be conducted. Fifty-nine participants with KOA will be recruited in a 1:1:1 ratio. Assessor, and statistician will be blinded to group allocation. One experimental group (n=19) will receive NME plus PNE, the other experimental group (n=19) will receive isolated NME and the control group (n=19) will continue with usual care. The PNE will be adapted to the context of the participants. Outcome measures will be brain activity, pressure pain threshold, pain intensity, disability, fear-avoidance beliefs, self-efficacy, and pain catastrophizing. Outcome measures will be evaluated pre-intervention, immediately post-intervention, and four-month post-intervention. The investigators hypothesize that there will be significant differences in favor of the NME plus PNE intervention group.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
OTHER	Neuromuscular exercise plus pain neuroscience education	The exercises follow neuromuscular principles, which aim to improve sensorimotor control and achieve compensatory functional stability (also called dynamic stability). Pain neuroscience education will take an active, person-centered approach through their own fear-avoidance beliefs.
OTHER	Neuromuscular exercise	The exercises follow neuromuscular principles, which aim to improve sensorimotor control and achieve compensatory functional stability (also called dynamic stability).

Timeline

• Start date: 2025-03-15
• Primary completion: 2025-11-30
• Completion: 2025-12-30
• First posted: 2024-07-01
• Last updated: 2024-07-01