NCT06480591

Evaluation of the Pathobiology of CALR-mutated MPN Cells

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 35 (estimated)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations.

Detailed description

This biospecimen study is designed to evaluate the expression levels of TLR 2 and TLR 4 on mononuclear cells in CALR mutation positive MPN participants and compare to JAK2 V617F mutation positive MPN patients and healthy controls. Patients who have MPN with the CALR mutation positive will be approached for interest in participating in this study. A research blood collection will occur at any time during the participant's cancer trajectory after enrollment, during a standard of care blood draw. The participant's demographics, MPN subtype, CALR mutation status, history of thrombosis/other medical history, and current, concomitant medications will be collected once. Clinical data will be collected, including results from the CBC with differential, complete metabolic panel (if available), and PT/PTT/INR (if available) drawn closest to the research blood collection. This study will initially open as a single center study at AHWFBCCC.

Conditions

• Myeloproliferative Neoplasm

Interventions

Type	Name	Description
OTHER	Blood Draw	The amount of blood that will be collected for this is 50 mL(milliliters), or about 3 ½ tablespoons.

Timeline

• Start date: 2025-01-21
• Primary completion: 2026-07-01
• Completion: 2026-09-01
• First posted: 2024-06-28
• Last updated: 2026-02-25

Locations

2 sites across 1 country: United States