NCT06478602

Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Cristian Ichim · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aims to investigate the beneficial effects of fecal transplantation in patients diagnosed with liver cirrhosis (regardless of etiology).

Detailed description

Participants in the experimental group will receive fecal microbiota transplantation (FMT) from a screened healthy donor. Each patient will undergo colonoscopic delivery of a minimum of 70 grams of donor fecal material into the cecum. The study will assess outcomes by monitoring clinical status, laboratory tests, imaging results and stool analyses (including assessment of micro-RNA profiles), comparing changes from baseline and with the control group. Participants will undergo scheduled re-evaluations at approximately 1 month post-transplant (timing may vary slightly due to clinical or logistical considerations).

Conditions

• Liver Cirrhosis

Interventions

Type	Name	Description
BIOLOGICAL	Fecal microbiota transplantation	Performing a colonoscopy with fecal microbiota transplantation at the level of the cecum.

Timeline

• Start date: 2024-08-05
• Primary completion: 2024-12-30
• Completion: 2025-03-31
• First posted: 2024-06-27
• Last updated: 2026-03-27
• Results posted: 2026-03-27

Locations

1 site across 1 country: Romania