NCT06477627

The Coastal Exposome: a Study of Sea Air Inhalation and Possible Links to Health

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 67 (actual)
• Sponsor: University Ghent · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The research aims to understand oceans as crucial contributors to human health in coastal environments. Oceans produce marine spray aerosols that contain a mixture of microbiota and natural biological molecules (biogenics).

Detailed description

The primary outcome envisioned consists of 2 goals. 1. In this study, the first objective is to determine whether the microbiota and biogenic molecules found in sea air are also found in the nasal swabs of the participants. In this way, the investigators will gain an understanding of which sea air components are inhaled by humans and how this changes over time. 2. Second, the investigators want to get an idea of whether these inhaled sea air components have an effect on certain pathways in the human body. In the in vitro study with cell lines, effects were already seen of sea air exposure on certain pathways in the body. Now the second goal of this study, is to see if changes in immunity biomarkers (IL-6, TNF-alpha, IL-10) are seen in vivo in humans. The Investigators will do this by taking VAMS blood samples from the participants.

Conditions

• Immune Suppression
• Exposure

Interventions

Type	Name	Description
OTHER	change of environment	The participants will change from inland to coastal environment to see the effect. We will take VAMS blood samples and nose swabs from the participant to measure this effect.
OTHER	no intervention	reference groups, stay in their coastal or inland environment

Timeline

• Start date: 2024-06-19
• Primary completion: 2024-12-31
• Completion: 2028-12-31
• First posted: 2024-06-27
• Last updated: 2024-08-21

Locations

1 site across 1 country: Belgium