NCT06476288

RIC (Remote Ischemic Conditioning) in Older Individuals

Feasibility and Acceptability of Remote Ischemic Conditioning to Achieve High-Intensity Rehabilitation Effects and Increase Resilience in Older Individuals

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the feasibility and acceptability of a technique called remote ischemic conditioning (RIC) that aims to improve muscle strength, muscle mass, exercise tolerance, resilience (i.e. how well someone responds to a stressor), quality of life, physical activity, and physical function when added to rehabilitative exercise training in individuals over age 65 who have some difficulty with mobility.

Conditions

• Old Age
• Mobility Limitation
• Debility

Interventions

Type	Name	Description
OTHER	Low-intensity resistance exercise training	The intervention protocol will consist of 60 minutes of low-intensity resistance exercise training 3x/week for 6 weeks.
OTHER	High-Dose Remote ischemic conditioning (RIC)	Treatment dose of RIC- the RIC cuff will be inflated to 20 mmHg over the participant's systolic blood pressure. The treatment dose of RIC will be applied in 4 sets of cycles with inflating the cuff and leaving it pumped for 5 minutes then deflating the cuff for an off period of 5 minutes. Total treatment time will be 35 minutes.
OTHER	Low-Dose Remote ischemic conditioning (RIC)	This dose will be the control for the study. Low-dose RIC- the RIC cuff will be inflated to 10 mmHg below the participant's diastolic blood pressure. The low-dose RIC will be applied in 4 sets of cycles with inflating the cuff and leaving it pumped for 5 minutes then deflating the cuff for an off period of 5 minutes. Total treatment time will be 35 minutes.

Timeline

• Start date: 2024-09-30
• Primary completion: 2026-06-01
• Completion: 2026-07-01
• First posted: 2024-06-26
• Last updated: 2025-12-16

Locations

1 site across 1 country: United States