NCT06473610

Residual Embolism Evaluated With Single Photon Emission Computed Tomography

Residual Embolism Evaluated With Single Photon Emission Computed Tomography - The RESPECT Cohort

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 358 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Major progress achieved in diagnostic and therapeutic strategies has substantially improved the short-term prognosis of patients with pulmonary embolism (PE). These improvements have led to a shift from an acute to a chronic condition of venous thromboembolism, justifying the recent development of Chronic Thrombo-embolic Disease (CTED). In most of the situations, it is due to a residual pulmonary vascular obstruction (RPVO) which can be assessed by pulmonary scintigraphy.

Detailed description

Planar ventilation/perfusion (V/Q) scintigraphy is the gold standard, but for several months, V/Q single photon emission computed tomography (SPECT) is recommended in the guidelines. The aim of this study is to evaluate the performances of various SPECT protocols to quantified RPVO and compared to planar scintigraphy to evaluate the RPVO.

Conditions

• Pulmonary Circulation Obstruction

Timeline

• Start date: 2024-06-27
• Primary completion: 2026-04-01
• Completion: 2026-04-01
• First posted: 2024-06-25
• Last updated: 2025-08-07

Locations

1 site across 1 country: France