NCT06473506

Group A Streptococcus Saliva Study

Exploring the Use of Saliva for the Detection of Group A Streptococcus

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 0 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

This study is being done to evaluate whether saliva can be used to diagnose GAS infection and also to compare different testing methods in the microbiology lab. The saliva sample testing will be compared to the throat swab testing to see if saliva testing works as well. The lab will also try different testing methods to see if a faster type of testing (e.g. molecular testing) works as well as the regular method, which takes 48 hours to get results. This is important because throat swabs can be challenging to collect in some children, and saliva is often much easier and more acceptable by children to collect. This could improve our ability to accurately diagnose and treat GAS infections.

Conditions

• Group A Streptococcal Infections

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Saliva collection	Self-collected saliva sample with molecular testing performed. Results are compared to rapid antigen testing, bacterial throat culture and bacterial throat molecular testing

Timeline

• Start date: 2024-06-10
• Primary completion: 2025-02-28
• Completion: 2026-04-30
• First posted: 2024-06-25
• Last updated: 2025-11-26

Locations

2 sites across 1 country: Canada