NCT06471309

Effect of Theta Burst Transcranial Magnetic Stimulation on Patients with Dysphagia After Stroke

Effect of Theta Burst Transcranial Magnetic Stimulation on Post-Stroke Dysphagia

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Zhang Xiaohui · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to observe the effect of Theta burst transcranial magnetic stimulation (TBS) on swallowing function in patients with dysphagia after stroke (PSD). Functional near- infrared spectroscopy (fNIRS) was used to detect the changes in activation and functional connectivity of related brain regions in PSD patients treated with intermittent TBS（iTBS）stimulation on the affected side and consistent TBS（cTBS） stimulation on the healthy side. To investigate the effects of TBS on swallowing related cortical excitability in stroke patients with dysphagia and explore its possible mechanism, and provide theoretical basis for the treatment of PSD patients.

Conditions

• Stroke
• Dysphagia
• Functional Near- Infrared Spectroscopy
• Transcranial Magnetic Stimulation

Interventions

Type	Name	Description
DEVICE	Theta burst transcranial magnetic stimulation	The stimulation intensity of TBS was 80%RMT, with a total of 600 pulses, five times a week for two weeks. In the bilateral stimulation group, iTBS treatment was given to the representative area of mylohyoid cortex on the affected side and cTBS treatment was given to the representative area of mylohyoid cortex on the healthy side. In the unilateral stimulation group, iTBS treatment was given to the representative area of mylohyoid cortex on the affected side and sham cTBS treatment was given to the representative area of mylohyoid cortex on the healthy side. In the sham stimulation group, sham iTBS treatment was given to the representative area of mylohyoid cortex on the affected side and sham cTBS treatment was given to the representative area of mylohyoid cortex on the healthy side. When giving sham stimulation, put the coil vertically so that the coil is perpendicular to the patient's skull surface , it will not produce real therapeutic effect.

Timeline

• Start date: 2024-08-02
• Primary completion: 2025-11-15
• Completion: 2025-12-15
• First posted: 2024-06-24
• Last updated: 2024-09-27

Locations

1 site across 1 country: China