NCT06470711

Mapping of Electrical Properties in the Brain

Mapping of Electrical Properties in the Brain.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study evaluates imaging methods for monitoring neural and electrical activity in the brain for improving clinical diagnosis.

Detailed description

PRIMARY OBJECTIVES: I. Optimize pulse sequence acquisitions for diffusion imaging on clinical MRI vendor systems. II. Develop image-based MRI models (including diffusion-based MRI) that accurately depict the multi-regional electrical properties in the brain (e.g., resistivity, current) to inform of neural integrity and function (including white matter tract integrity) in diseased and non-diseased states. III. Compare/correlate image-based MRI models (e.g., diffusion) with existing structural, physiologic, and functional MRI methods (e.g., tensor imaging, fMRI, DSC-MRI, etc). IV. Further train image-based models/measurements with loco-regional benchmarks including (but not exclusive to) electrophysiologic monitoring, functional and structural tissue assays (from available biopsies), and correlative clinical features (e.g., histology, outcomes, treatment, etc). OUTLINE: This is an observational study. Participants complete a survey and undergo MRI on study.

Conditions

• Malignant Glioma

Interventions

Type	Name	Description
OTHER	Non-Interventional Study	Non-interventional study

Timeline

• Start date: 2024-09-13
• Primary completion: 2027-09-30
• Completion: 2027-09-30
• First posted: 2024-06-24
• Last updated: 2026-02-03

Locations

1 site across 1 country: United States