NCT06469866

Deep Neuromuscular Block Affect the Quality of Recovery After Laparoscopic Hysterectomy

Effect of Deep Neuromuscular Block on the Quality of Recovery After Laparoscopic Hysterectomy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (estimated)
• Sponsor: Anqing Municipal Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

BACKGROUND: Some studies have revealed that deep neuromuscular block (NMB) improve surgical conditions and alleviated postoperative pain compared with moderate NMB. The present study investigated deep NMB could improve the quality of recovery after laparoscopic hysterectomy METHODS: seventy-two women with elective laparoscopic hysterectomy were randomly divided into 2 groups: Patients in group A received low-pressure pneumoperitoneum (LPP), which was set at 8-10 mmHg with deep NMB. Patients in group B received standard-pressure pneumoperitoneum (SPP), which was set at 12-14 mmHg with moderate NMB. Primary outcome was the quality of recovery (QoR-15) at 1 day after sugery. The secondary outcomes included postoperative pain, surgical condition, incidence of shoulder pain, the incidence of rescue analgesic drug use, cumulative dose of analgesics, time of first flatus, post-operative nausea and vomiting, time of tracheal tube removal.

Conditions

• Neuromuscular Blockade
• Laparoscopy

Interventions

Type	Name	Description
DEVICE	low-pressure pneumoperitoneum	low-pressure pneumoperitoneum (LPP) with deep NMB.
DEVICE	standard-pressure pneumoperitoneum	standard-pressure pneumoperitoneum (SPP) with moderate NMB.

Timeline

• Start date: 2024-06-25
• Primary completion: 2024-11-25
• Completion: 2024-11-25
• First posted: 2024-06-24
• Last updated: 2024-06-24

Locations

1 site across 1 country: China