NCT06463990

Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia

Association Between the Triglyceride-glucose Index and the Ratio of Triglyceride to High-density Lipoprotein Cholesterol With Fetal Macrosomia in Low-risk Nulliparous Pregnant Women

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 302 (actual)
• Sponsor: Ankara Etlik City Hospital · Other Government
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus. The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality. While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.

Detailed description

In this study, the investigators aimed to investigate whether the ratio of triglycerides to high-density lipoprotein cholesterol and the triglyceride glucose index are associated with fetal macrosomia in low-risk nulliparous pregnant women.

Conditions

• Fetal Macrosomatia
• Lipid Metabolism Disorders
• Hyperlipidemias

Interventions

Type	Name	Description
OTHER	TyG index	association between TyG index and triglyceride to high-density lipoprotein cholesterol ratio with fetal macrosomia

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-07-30
• Completion: 2024-08-25
• First posted: 2024-06-18
• Last updated: 2024-09-03

Locations

1 site across 1 country: Turkey (Türkiye)