NCT06462521

Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection

Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection: A RandomizeD Trial IN Colorectal Adenomas 10-19mm and Serrated Lesions ≥ 10mm (CARDINAL Study)

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 570 (estimated)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will compare the use of cold snare piecemeal resection (CSPR) vs cold endoscopic mucosal resection (Cold EMR). The study will include two cohorts: one cohort for conventional adenomas 10-19mm in size and one cohort for serrated lesions 10mm or larger.

Conditions

• Colon Cancer
• Colon Polyp
• Colon Adenoma
• Serrated Polyp

Interventions

Type	Name	Description
PROCEDURE	Cold Snare Piecemeal Resection (CSPR)	Qualifying polyps randomized to Cold Snare Piecemeal Resection (CSPR) will be removed using cold snare techniques (no electrocautery, no submucosal injection.)
PROCEDURE	Cold Snare Endoscopic Mucosal Resection (Cold EMR)	Qualifying polyps randomized to Cold Snare Endoscopic Mucosal Resection (Cold EMR) will be removed using cold snare techniques (no electrocautery, with submucosal injection.)

Timeline

• Start date: 2024-09-06
• Primary completion: 2027-07-01
• Completion: 2028-07-01
• First posted: 2024-06-17
• Last updated: 2025-12-30

Locations

1 site across 1 country: United States