NCT06457087

Optical Biopsy for Peripheral Pulmonary Lesions

Confocal Laser Endomicroscopy in the Diagnosis of Peripheral Pulmonary Lesions

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Shanghai Chest Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to describe confocal laser endomicroscopy (CLE) interpretation criteria for different types of peripheral pulmonary lesions (PPLs), with histopathological correlation, and to perform the validation of these criteria.

Detailed description

CLE is a modern imaging technique that uses an excitation laser light to create real-time microscopic images of tissues. During transbronchial lung biopsy, CLE has the potential to provide real-time non-invasive diagnosis of PPLs ("optical biopsy"). In this study, we will obtain CLE images within the target lesion before taking a biopsy during transbronchial lung biopsy of PPLs. We will compare the results of the "optical biopsy" with the corresponding histopathological results and develop CLE interpretation criteria for different types of PPLs. In addition, we will perform the validation of these criteria to evaluate the ability of CLE to discriminate between benign and malignant PPLs.

Conditions

• Peripheral Pulmonary Lesions

Timeline

• Start date: 2024-06-01
• Primary completion: 2024-12-01
• Completion: 2025-06-01
• First posted: 2024-06-13
• Last updated: 2024-06-14

Locations

1 site across 1 country: China