NCT06456736

Clinical Features and Prognostic Markers in Adult Patients With AE Requiring ICU Treatment

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Central South University · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

Autoimmune encephalitis (AE) is a potentially life-threatening inflammation of the central nervous system (CNS) and constitutes 20%-30% of encephalitis cases in adults AE often leads to subacute, severe, and debilitating encephalitis necessitating long-term management in a neurologic intensive care unit (ICU). This study aims to explore the predictive factors for poor clinical outcomes by analyzing the clinical characteristics and prognosis of adult patients with critical AE requiring ICU admission. Prospective observational single center study in neurologic ICU, the second Xiangya hospital, Central South University. All patients admitted to the ICU for probable or confirmed AE (2022 Chinese guidelines for diagnosis and treatment of AE) will be included. Factors associated with a poor prognosis will be identified by multivariate analysis using a logistic regression.

Conditions

• Autoimmune Encephalitis

Interventions

Type	Name	Description
OTHER	None, non-interventional study	Not applicable, non-interventional study

Timeline

• Start date: 2024-06-01
• Primary completion: 2024-07-01
• Completion: 2024-08-01
• First posted: 2024-06-13
• Last updated: 2024-06-13