NCT06451874

Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome

Motoric Cognitive Risk Syndrome: Refining Treatment Strategies and Testing Feasibility to Personalize Treatment for Older Veterans

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).

Detailed description

This study will involve therapeutic exercise treatments for Veterans with pre-clinical dementia syndrome. Participants will either participate in functional power training, music-based walking training, or a combination of both. The study will use a sequential multiple assignment, randomized trial (SMART) design. Successful completion of this study will lay the foundation for subsequent research trials, contributing to valuable evidence for personalized rehabilitation medicine for older Veterans.

Conditions

• Motoric Cognitive Risk Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Functional Power Training (FPT)	Participants will receive twice weekly FPT, a progressive functional-based exercises that target optimizing leg force production and leg velocity.
BEHAVIORAL	Music-Based Digital Therapy (MBDT)	Participants will receive twice weekly MBDT, a technology-driven gait training that is grounded in evidence-based rehabilitation treatment, rhythmic auditory stimulation.
BEHAVIORAL	FPT + MBDT	For non-responders who were randomized to augment treatment, they will receive combined FPT and MBDT treatment.

Timeline

• Start date: 2025-07-01
• Primary completion: 2029-05-31
• Completion: 2029-12-31
• First posted: 2024-06-11
• Last updated: 2025-08-06

Locations

1 site across 1 country: United States