NCT06451302

Risk Stratification Oriented Treatment of Pediatric Ewing Sarcoma: a Prospective Multicenter Cohort Study

A Prospective Multicenter Cohort Study of Outcome and Safety Profile of Risk Stratification Oriented Treatment in Pediatric Ewing Sarcoma in China

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Yizhuo Zhang · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim is to evaluate the outcome and safety of risk-stratification oriented treatment for pediatric Ewing sarcoma in multicenters .

Detailed description

Pediatric Ewing sarcoma is stratified into three risk groups(low risk, moderate risk and high risk) accordiong to age, longest diameter of lesion, volume and tumor site. Participants receive chemotherapy with corresponding intensity. The prospective study is to assess efficacy, outcome and safety profile of different treatment received for pediatric Ewing sarcoma. The prospecitive single-arm study is to be conducted in Chinese multicenters.

Conditions

• Ewing Sarcoma
• Risk Stratification

Interventions

Type	Name	Description
DRUG	cyclophosphamide, adriamycin, vincristine，Ifosfamide，etoposide	The doses and intensity of chemotherapy vary according to risk stratification. Mainenance therapy is added to high-risk patients.

Timeline

• Start date: 2024-04-17
• Primary completion: 2027-05-31
• Completion: 2027-12-31
• First posted: 2024-06-11
• Last updated: 2024-06-11

Locations

1 site across 1 country: China