NCT06451237

Acne Remission Maintenance by Weekend Systemic Isotretinoin

Weekend Systemic Isotretinoin for Maintaining Acne Remission: A Novel Approach

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to learn if isotretinoin oral tablets as a weekend regimen are safe and effective to maintain freedom from acne lesions in young adults who have completed a full course of isotretinoin on daily basis and achieved total control of the acne activity.

Detailed description

Three groups of adult acne patients will be given a full course of isotretinoin with a cumulative dose of 120-150 mg/Kg weight in the 1st two groups, and till lesional clearance in the 3rd group with an additional month of maintenance. Afterwards, the 1st group will use adapalene gel every other day for maintenance, the 2nd and 3rd groups will use weekend oral isotretinoin. Patients will be followed for a year for reappearance of acne lesions, and safety of maintenance regimens. Patients opinion will be also sought.

Conditions

• Acne Vulgaris

Interventions

Type	Name	Description
DRUG	Isotretinoin capsules	A one year follow up for patients on three maintenance regimens after acne clearance, including weekend isotretinoin and adapalene gel.

Timeline

• Start date: 2018-01-20
• Primary completion: 2022-12-20
• Completion: 2023-09-20
• First posted: 2024-06-11
• Last updated: 2024-06-11

Locations

1 site across 1 country: Egypt