NCT06451133

Hemodynamic Management Following Acute Traumatic Spinal Cord Injury

Hemodynamic Management Following Acute Traumatic Spinal Cord Injury: A Randomized, Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 228 (estimated)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.

Conditions

• Spinal Cord Injuries

Interventions

Type	Name	Description
OTHER	Mean arterial blood pressure (MAP) goal of ≥65 mmHg	The treatment team will maintain MAP ≥65 mmHg for the first five days following injury.
OTHER	Mean arterial blood pressure (MAP) goal of 85-90 mmHg	The treatment team will maintain MAP 85-90 mmHg for the first five days following injury.
OTHER	Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg	The treatment team will maintain SCPP ≥65 mmHg for the first five days following injury.

Timeline

• Start date: 2024-07-03
• Primary completion: 2025-09-15
• Completion: 2026-07-31
• First posted: 2024-06-11
• Last updated: 2024-12-11

Locations

1 site across 1 country: United States