NCT06448325

Fragility Re-fractures Prediction Score

RIFRA - Re-fracture Risk Prediction in Patients With Fragility Fracture: Score Development and Validation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Fragility fractures increase among elderly patients worldwide, representing a global burden in terms of disability and care expenditure. Osteoporosis is asymptomatic up to the moment in which a first fracture occurs, reason why it is often underdiagnosed. Even after that, further fractures do occurr, as osteoporosis is often untreated. Several programs have been introduced worldwide to prevent secondary fractures among the population at risk (e.g., International Osteoporosis Foundation's Capture the Fracture), and several risk factors are being investigated to generate a predictive score. However, accurate validation is needed to make these scores reliable. In this retrospective observational study, we aim to validate a predictive score trained on a population of elderly patients with a cohort of patients who underwent hip fracture surgery in a high-volume orthopedic center in the Region of Lombardy.

Conditions

• Osteoporosis Risk

Interventions

Type	Name	Description
OTHER	Hip arthroplasty	Surgical treatment of the hip after osteoporosis fracture. The focus of the study is the prediction of further fractures (and therefore further surgical procedures) after the first one.

Timeline

• Start date: 2024-05-28
• Primary completion: 2024-10-31
• Completion: 2025-02-28
• First posted: 2024-06-07
• Last updated: 2024-06-07

Locations

1 site across 1 country: Italy