NCT06446622

Brain Blood Flow Responses During Exercise: Younger Cohort

Influence of Biological Sex and Age on Cerebral Blood Flow and Vessel Function During Exercise: a Pilot Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Brain blood flow will be measured during exercise using magnetic resonance imaging.

Detailed description

Over 6 million Americans are living with Alzheimer's disease and related dementias and this number is expected to reach over 13 million by 2060. Thus, there is an urgent need for interventions to prevent the development and progression of Alzheimer's disease and related dementias. Regular exercise is currently the most promising strategy as it is repeatedly shown to have neuroprotective benefits. Evidence suggests that the neuroprotective effects of exercise is the result of improved health of blood vessels. Despite the vast amount of evidence on the benefit of exercise on the peripheral vasculature, there is little information regarding brain vascular responses during exercise. This study will investigate the impact of exercise at varying intensities on brain blood flow during exercise, and will also examine the influence of age and sex. This record represents a younger cohort for the study represented in NCT05864950.

Conditions

• Cerebrovascular Circulation
• Magnetic Resonance Imaging

Interventions

Type	Name	Description
DEVICE	MRI	Participants will undergo an MRI scan while performing exercise at two intensities (light and moderate/vigorous) using an MRI-compatible stepper device.

Timeline

• Start date: 2023-04-18
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2024-06-06
• Last updated: 2025-07-18

Locations

1 site across 1 country: United States