NCT06441721

Vitamin B12 Status and Its Impact on Chronic Haemodialysis Patient

Vitamin b12 Deficency and Its Impact on Chronic Haemodialysis Patient and Its Effect on Anemia and Neuropathy

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

To evaluate vitamin B12 level in haemodialysis patients and its impact on hematological and neurological manifestations

Detailed description

Vitamin B12 (cobalamin) is a water-soluble vitamin involved in several normal cellular functions (1). Vitamin B12 is required for the development, myelination, and function of the central nervous system; healthy red blood cell formation; and DNA synthesis (2- 4). Low levels of vitamin B12 have been associated with high concentrations of homocysteine (Hcy) and can lead to health complications (5). Hyperhomocysteinemia is an important risk factor for cardiovascular disease (6). Vitamin B12 and other B vitamins are involved in homocysteine metabolism, and researchers have hypothesized that supplementation with these micronutrients can reduce the risk of cardiovascular disease by lowering homocysteine levels (7, 8). Vitamin B12 deficiency is one of the causes of Macrocytic anaemia with increased mean corpuscular volume (MCV), defined as more than 100 fL, which is the hallmark of megaloblastic anaemia

Conditions

• End Stage Renal Disease on Dialysis
• Vitamin B 12 Deficiency

Interventions

Type	Name	Description
DEVICE	Vitamin b12 measure	Measure vitamin b12 in serum and its impact on Haemodialysis patient

Timeline

• Start date: 2024-07-05
• Primary completion: 2025-07-01
• Completion: 2025-09-01
• First posted: 2024-06-04
• Last updated: 2024-06-06