NCT06441435

The Effect of AC-134 in Chronic Kidney Diseases

To Investigate the Protective Effect of AC 134 in Chronic Kidney Diseases.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Taichung Veterans General Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The objective is to explore the effects of adding AC-134 on renal function, proteinuria, uremic toxins, and metabolism-related markers in chronic kidney disease.

Detailed description

Chronic kidney disease (CKD) management primarily focuses on addressing associated complications such as hypertension, diabetes mellitus, cardiovascular disease, and proteinuria. In addition to standard therapies, reducing the accumulation of toxins, particularly gut-derived uremic toxins like indoxyl sulfate (IS) and p-cresol sulfate (PCS), may help alleviate uremia symptoms. This study assesses the impact of oral AC-134 capsules containing activated charcoal adsorbent on CKD patients. The assessment will include evaluating changes in renal function, proteinuria, uremic toxins, and metabolism-related markers.

Conditions

• Nephrology

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Low protein diet with AC-134	Low protein diet combined with AC-134 Dosage: 2 capsules,three times/day
OTHER	Standard treatment	Low protein diet

Timeline

• Start date: 2024-05-24
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-06-04
• Last updated: 2024-06-04

Locations

1 site across 1 country: Taiwan