NCT06441162

Efficacy Of Combined Nebulized Hypertonic Saline and Chest Percussion Therapy in Acute Viral Bronchiolitis

A Pilot, Non-randomized, Single-site Clinical Study Investigating the Efficacy of Combined Therapy of Nebulized 3% Hypertonic Saline and Chest Percussion Therapy in Pediatric Patients With Acute Viral Bronchiolitis.

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 0 Months – 24 Months
• Healthy volunteers: Not accepted

Summary

This study will examine the efficacy of combined nebulized hypertonic saline with chest percussion therapy in patients age 0 to 24 months admitted to the general inpatient pediatrics unit with acute bronchiolitis. 3% nebulized hypertonic saline treatments combined with 3 minutes of chest percussion therapy will be administered every 6 hours of patients selected for the study.

Conditions

• Acute Bronchiolitis

Interventions

Type	Name	Description
DRUG	Nebulized 3% sodium chloride solution	Standardized dose of nebulized 3% sodium chloride will be provided from 4 mL vial and administered be every 6 hours.
DEVICE	Chest percussion cups	The chest percussion cup is a small, flexible cup made of vinyl that is used to provide gentle chest wall vibrations to assist with airway clearance and is utilized in patients of all ages with sputum production, such as those with acute bronchiolitis. Administered every 6 hours while on supplemental oxygen therapy.

Timeline

• Start date: 2024-07-15
• Primary completion: 2025-05-15
• Completion: 2025-05-15
• First posted: 2024-06-04
• Last updated: 2026-02-20
• Results posted: 2026-02-20

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study
• FDA-regulated device study