NCT06439355

Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (estimated)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: * healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease. To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data. This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.

Conditions

• Idiopathic Parkinson's Disease and Lewy Body Disease

Interventions

Type	Name	Description
BIOLOGICAL	Fasting blood test	metabolic assays determination of food intake hormones oxidative stress and neurodegeneration marker assays
OTHER	Subject interview	socio-demographic data, medical and family history, treatment taken
OTHER	Motor assessment	MDS-UPDRS scale PART III
OTHER	Neurocognitive assessment	MoCA and MMSE scales
OTHER	Nutritional assessment	anthropometric data (weight, height, BMI, waist circumference, hip circumference, android/gynoid ratio, triceps skin fold, brachial circumference), bioelectrical impedancemetry (fat mass, lean mass, water mass and bone mass)
OTHER	Taste tests	Recording of PEGs in response to a sucrose solution and a free fatty acid solution (prepared beforehand)

Timeline

• Start date: 2024-05-27
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2024-06-03
• Last updated: 2024-06-07

Locations

1 site across 1 country: France