NCT06437873

Long-term Survival Outcomes of Total Thyroidectomy and Radioactive Iodine Therapy in Unilateral T3/T4 FTC

Long-term Survival Outcomes of Total Thyroidectomy and Radioactive Iodine Therapy in Unilateral T3/T4 Follicular Thyroid Carcinoma:A Retrospective Propensity Score-Matched Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,957 (actual)
• Sponsor: Dezhou Hospital Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 5 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This study aims to thoroughly examine survival disparities in patients with T3 or T4 stage follicular thyroid carcinoma (FTC) as classified by the AJCC staging system. It compares outcomes between those who underwent total thyroidectomy (TT) and those who did not, and assesses the influence of radioactive iodine therapy (RAIT) on the survival of patients without TT. Utilizing the SEER database, a retrospective study identified patients diagnosed with T3 or T4 FTC, categorizing them into two cohorts: those treated with TT and those who were not (No-TT). The No-TT group was further analyzed to determine the impact of RAIT on patient survival. Propensity score matching (PSM) was applied to adjust for confounding variables. Survival analysis, including Kaplan-Meier survival curves and Landmark analysis, was conducted to evaluate the effects of surgical intervention and RAIT on overall survival (OS) and cancer-specific survival (CSS).

Conditions

• Follicular Thyroid Cancer
• SEER Database Analysis

Interventions

Type	Name	Description
PROCEDURE	Total Thyroidectomy (TT)	TT:Surgical removal of the entire thyroid gland.
RADIATION	Radioactive iodine treatment(RAIT)	RAIT:Administration of radioactive iodine to eliminate remaining thyroid tissue or cancer cells.

Timeline

• Start date: 2000-01-01
• Primary completion: 2020-12-31
• Completion: 2024-05-25
• First posted: 2024-05-31
• Last updated: 2024-05-31