NCT06436846

Genomic Risk in Retroperitoneal Sarcoma

Characterization of the Genomic Risk Underlying Retroperitoneal Liposarcoma

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Fox Chase Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.

Conditions

• Retroperitoneal Liposarcoma
• Soft Tissue Sarcoma

Interventions

Type	Name	Description
OTHER	Biospecimen sample collection during standard-of-care surgery	Patients in this observational study are undergoing planned surgical resection of their retroperitoneal sarcoma as prescribed by their primary surgeon and treatment team. In addition to removal of the primary tumor, surgeons remove 4 samples of retroperitoneal fat and a sample of subcutaneous fat for further study at the time of the operation.

Timeline

• Start date: 2022-03-07
• Primary completion: 2027-06-30
• Completion: 2027-08-01
• First posted: 2024-05-31
• Last updated: 2024-05-31

Locations

1 site across 1 country: United States