NCT06435065

Direct Pulp Capping Agent on Human Pulp Tissue

Histological and Radiographic Evaluation of the Effects of Direct Pulp Capping Agent on Human Pulp Tissue

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: DR SURINDER SACHDEVA · Academic / Other
• Sex: All
• Age: 15 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This in- vivo study was conducted to evaluate the response of human pulp tissue following direct pulp capping using four different pulp capping agents in premolars scheduled for extraction in patients undergoing orthodontic treatment.

Detailed description

For the study 40 premolars from patients in the age group of 15-25 years, undergoing orthodontic treatment, in the Department of Orthodontics, MMCDSR, Mullana, Ambala, who had to get their premolars extracted as per their orthodontic treatment plan will be selected. Only healthy premolars, with no caries, showing no signs and symptoms of pulpitis or periodontal diseases were selected. Medically compromised patients, or teeth with radiographic findings of external/internal resorption, bone loss, or calcifications in the pulp chamber will be excluded from the study. The selected premolars were then randomly divided into four equal groups namely: GROUP I - Direct pulp capping procedure performed using Biodentine. GROUP II - Direct pulp capping procedure performed using MTA. GROUP III - Direct pulp capping procedure performed using TheraCal LC. GROUP IV - Direct pulp capping procedure performed using Tristrontium aluminate. The direct pulp capping procedure was carried out under rubber dam. The study protocol included class I cavity preparations on the premolars, followed by iatrogenic exposure of the pulp (0.5mm) using a sterile round bur, placement of the direct pulp capping agent according to the material of allotted to the study group. The teeth were permanently restored on the same visit, except for MTA group were the teeth were temporarily restored using Cavit G, and recalled after 1 day for permanent restoration. The patients were then enquired for any 94 SUMMARY 95 symptoms at 1 day and 7 days post operatively. The teeth were then, atraumatically extracted 3 months after the procedure. The extracted teeth were then put to CBCT as well as histopathological examination. Through CBCT evaluation, the completeness of the dentine bridge was evaluated. Histopathological examination was done to examine the pulpal response and the quality of the dentine bridge formed

Conditions

• Reversible Pulpitis

Interventions

Type	Name	Description
DRUG	Biodentine	DIRECT PULP CAPPINGWILL BE DONE USING BIODENTINE
DRUG	Mineral Tri-Oxide Aggregate	DIRECT PULP CAPPINGWILL BE DONE USING MTA
DRUG	THERACAL LC	DIRECT PULP CAPPINGWILL BE DONE USING THERACAL LC
DRUG	TRISTRONTIUM ALUMINATE	DIRECT PULP CAPPINGWILL BE DONE USING TRISTRONTIUM ALUMINATE

Timeline

• Start date: 2024-04-01
• Primary completion: 2024-06-01
• Completion: 2024-07-01
• First posted: 2024-05-30
• Last updated: 2024-05-30

Locations

1 site across 1 country: India