NCT06431789

Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 220 (estimated)
• Sponsor: Yi Han · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

1. To provide reference for clinical rational use of edoxaban; 2. Optimize the individualized dosing regimen of edoxaban.

Detailed description

In this study, patients with moderate and severe renal insufficiency receiving edoxaban were selected as research objects. The potential safety of edoxaban in patients with different genotypes was evaluated by detecting the anti-XA factor activity and SLCO1B1 genotyping, so as to optimize the individualized administration regimen of edoxaban.

Conditions

• Gene Polymorphism
• Edoxaban
• Renal Insufficiency

Timeline

• Start date: 2024-05-01
• Primary completion: 2025-10-31
• Completion: 2026-04-30
• First posted: 2024-05-29
• Last updated: 2024-05-29

Locations

1 site across 1 country: China