NCT06430918

Neuropathic Pain and it's Relation to Sleep Quality in Knee Osteoarthritis

Coexistence of Night Pain and Neuropathic Pain in Patients With Knee Osteoarthritis

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Bozyaka Training and Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The primary aim is to investigate the frequency and severity of neuropathic pain and its association with night pain in patients with knee osteoarthritis. For this purpose a progressive longitudinal study design was planned. The secondary aim is to investigate the relationship between night pain and neuropathic pain and sleep quality.

Detailed description

Osteoarthritis (OA) is the most common form of arthritis in the world. Classically, OA presents with joint pain and loss of function; however, the disease is clinically very variable and can present merely as an asymptomatic incidental finding to a devastating and permanently disabling disorder. The severity of knee pain caused by osteoarthritis, often does not correlate with the degree of degenerative changes in the joint. In patients reporting night pain, this may be related to inflammation, but in the absence of clinical and laboratory findings of inflammation, it is not possible to explain night pain only by the degree of joint damage. The existence of a relationship between night pain and neuropathic pain may be a guide in looking for neuropathic pain in patients who have night pain and experience this pain severely and thus for planning an appropriate treatment for the patient. Patients with stage 2-4 knee OA will be evaluated in terms of demographic variables and outcome measurement parameters specified in the case report form. The relationship between neuropathic pain scores and knee pain severity will be sought. It will be studied whether there is a difference in outcome measurement parameters between those with neuropathic pain and those without. Correlation analysis will be performed between sleep quality score and pain intensity scores. The determinants of sleep quality will be evaluated by regression analysis. American College of Rheumatology criteria will be recruited. Demographics and disease related variables will be recorded.

Conditions

• Knee Osteoarthritis
• Sleep Disturbance
• Neuropathic Pain

Interventions

Type	Name	Description
OTHER	physical examination, questionnaires and inventories	Questionnaires and inventories related to primary end secondary outcomes will be applied and physical examination will be performed.

Timeline

• Start date: 2024-05-16
• Primary completion: 2026-12-01
• Completion: 2027-07-30
• First posted: 2024-05-28
• Last updated: 2025-11-14

Locations

1 site across 1 country: Turkey (Türkiye)