NCT06430489

Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide

Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide - PROTORISC Pilote

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University Hospital, Tours · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Suicide prevention is a major public health concern, with nearly 9,000 suicides and over 200,000 suicide attempts reported each year in France. Suicide attempts and suicidal ideation are among the most frequent reasons for emergency room visits and psychiatric hospitalizations. Although there is no approved pharmacological treatment for suicidal crises, some psychiatric treatments appear promising. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has shown promising results in reducing suicidal ideation. However, its use is limited due to its side effects. Nitrous oxide, another NMDA receptor inhibitor commonly used in anesthesia and pain management, has demonstrated rapid antidepressant effects and few side effects. Given its rapid and lasting effects, nitrous oxide could swiftly alleviate suicidal ideation.

Conditions

• Suicidal Ideation
• Emergency Psychiatric
• Nitrous Oxide

Interventions

Type	Name	Description
DRUG	Nitrous oxide	inhaled nitrous oxide (1 hour at 50% concentration)
DRUG	Medical air	inhaled medical air (1 hour)

Timeline

• Start date: 2024-06-01
• Primary completion: 2025-12-01
• Completion: 2026-01-01
• First posted: 2024-05-28
• Last updated: 2024-06-07

Locations

1 site across 1 country: France