NCT06430372

Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract

Study of Vascular Endothelial Growth Factor A Targeting NIR-II Fluorescence in the Endoscopy of Gastrointestinal Tract

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Institute of Automation, Chinese Academy of Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

In this study, the investigators are studying new ways to look for abnormal tissues of the gastrointestinal tract during an endoscopy. We are using a VEGF-A targeting fluorescent probe and a NIR-II fluorescent endoscope to help detect abnormal tissues that are hard to see by the naked eye. The main purposes of this study include: 1. To translate the NIR-II approach into the endoscopy, and understand its advantages and limitations on detecting abnormal tissues in gastrointestinal. 2. To validate whether topical administration of a targeting probe can stick to abnormal tissues and be detected by the NIR-II endoscope. 3. To validate the safety and effectiveness of the topical administration of VEGF-A targeting probes for clinical application.

Conditions

• Gastrointestinal Carcinoma
• Dysplasia
• Gastrointestinal Polyp

Interventions

Type	Name	Description
DRUG	Bev-ICG	Probe targeting VEGF-A that is topically administrated during the endoscopy
DEVICE	NIR-II fluorescence endoscopy platform	An endoscopic detection device which can detect and visualize NIR-II fluorescent signal during the endoscopy

Timeline

• Start date: 2023-07-20
• Primary completion: 2025-05-30
• Completion: 2026-05-30
• First posted: 2024-05-28
• Last updated: 2025-05-13

Locations

1 site across 1 country: China