NCT06426979

Sequential Letrozole and Methotrexate Therapy Role in Treatment of Tubal Ectopic Pregnancy

Sequential Letrozole and Methotrexate Therapy Safely Improved the Outcomes of Medical Treatment of Tubal Ectopic Pregnancy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: Female
• Age: 22 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Ectopic pregnancy (EP) is a common condition involving the implantation of fertilized ovum outside the uterine cavity, accounting for 1-2% of all pregnancies. Tubal EP (TEP) is the most common and poses a significant risk to maternal life. Early diagnosis and medical treatment, such as methotrexate (MTX) and the Fallopian tube (FT), have been studied. However, the efficacy of single-dose methotrexate (SD-MTX) is questionable, and the efficacy of two-dose versus SD-MTX for medical management of EP is being evaluated. High estrogens/progesterone ratios can disrupt embryonic motility and lead to TEP.

Conditions

• Pregnancy Tubal

Interventions

Type	Name	Description
DRUG	Methotrexate	Methotrexate 25 mg/ml was given as single-dose of intramuscular (IM) injection in a dose of 50 mg/m2.
DRUG	Letrozole	FEMARA 2.5 mg tablets two tablets daily

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-06-01
• Completion: 2024-01-01
• First posted: 2024-05-23
• Last updated: 2024-05-28

Locations

1 site across 1 country: Egypt