Trials / Recruiting
RecruitingNCT06426836
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- Sponsor
- University Hospital, Ghent · Academic / Other
- Sex
- All
- Age
- 15 Years
- Healthy volunteers
- Not accepted
Summary
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
Detailed description
The study will investigate whether - with the current dosing regimens of meropenem, piperacillin-tazobactam, amoxicillin-clavulanate, cephazolin, vancomycin, amikacin, teicoplanin and ciprofloxacin - pharmacodynamic targets are attained in a national multicentric clinical setting in pediatric patients on ECMO.
Conditions
- Pharmacokinetics
- Amoxicillin-clavulanate
- Piperacillin-tazobactam
- Meropenem
- Cefazolin
- Teicoplanin
- Vancomycin
- Ciprofloxacin
- Amikacin
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Amoxicillin-clavulanate | blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care |
| OTHER | Piperacillin-tazobactam | blood sampling in patients receiving piperacillin-tazobactam as part of routine clinical care. |
| OTHER | Meropenem | blood sampling in patients receiving meropenem as part of routine clinical care. |
| OTHER | Cefazolin | blood sampling in patients receiving cefazolin as part of routine clinical care. |
| OTHER | Vancomycin | blood sampling in patients receiving vancomycin as part of routine clinical care. |
| OTHER | Teicoplanin | blood sampling in patients receiving teicoplanin as part of routine clinical care. |
| OTHER | Ciprofloxacin | blood sampling and urine sampling in patients receiving ciprofloxacin as part of routine clinical care. |
| OTHER | Amikacin | blood sampling in patients receiving amikacin as part of routine clinical care. |
Timeline
- Start date
- 2016-08-19
- Primary completion
- 2026-07-01
- Completion
- 2026-07-01
- First posted
- 2024-05-23
- Last updated
- 2026-01-16
Locations
3 sites across 1 country: Belgium
Source: ClinicalTrials.gov record NCT06426836. Inclusion in this directory is not an endorsement.