NCT06425822

Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to analyze the characteristics of left atrial electroanatomical maps in patients without a history of atrial fibrillation but with a high clinical risk of developing it, as indicated by the presence of structural heart disease or a CHA2DS2-VASc score ≥ 2 points. The study cohort will be compared to a historical cohort of patients with diagnosed atrial fibrillation in a propensity-matched fashion. The main questions it aims to answer are: * Are the left atrial electroanatomical changes a consequence or a precursor to the development of atrial fibrillation? * Are the left atrial electroanatomical findings different between patients with atrial fibrillation and those at high risk of developing it? * What is the prognostic impact of left atrial pathologic changes in patients without diagnosed atrial fibrillation in terms of cardiovascular outcomes?

Conditions

• Atrial Remodeling

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Left atrial electroanatomical mapping	Left atrial electroanatomical mapping (substrate and functional mapping)

Timeline

• Start date: 2023-11-08
• Primary completion: 2025-10-31
• Completion: 2027-10-31
• First posted: 2024-05-22
• Last updated: 2024-05-22

Locations

1 site across 1 country: Belgium