NCT06423807

Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section

Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to estimate the role of ondansetron lozenge on prevention of post-spinal shivering in cesarean section.

Detailed description

Spinal anesthesia (SA) is preferred for cesarean section (CS) compared with general anesthesia(GA) because of several advantages, including prevention of the potential risk of GA-related neurotoxicity. Post-spinal shivering (PSS) could be a provocative factor for postoperative pain and its appropriate treatment prevents non-thermoregulatory tremors. Shivering also causes aggravating postoperative pain by stretching of sutures. Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operation. Ondansetron can affect the body temperature and shivering in rats since the balance of nor-epinephrine and 5-hydroxytryptamine (5-HT) in the preoptic-anterior hypothalamus controls the temperature set point.

Conditions

• Ondansetron Lozenge
• Post-Spinal Shivering
• Cesarean Section

Interventions

Type	Name	Description
DRUG	Ondansetron lozenge	Patients will receive ondansetron lozenge 4 mg (Ondalenz ©), 2 hours before surgery.

Timeline

• Start date: 2024-05-21
• Primary completion: 2024-09-29
• Completion: 2024-09-29
• First posted: 2024-05-21
• Last updated: 2024-10-08

Locations

1 site across 1 country: Egypt