NCT06423560

Pulmonary Fibrosis After Severe COVID-19 Pneumonia

Evaluation of Pulmonary Fibrosis After Severe Interstitial Pneumonia Due to COVID-19 (SARS-CoV-2)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 61 (actual)
• Sponsor: IRCCS San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients discharged after hospitalization for COVID-19 pneumonia were retrospectively selected by radiologically established criteria that at admission presented at chest computed tomography (CT) (i) normal lung parenchyma \<50% of total lung volume; and/or (ii) area of lung consolidation \> 10%. All At discharge and after 9 months, all subjects underwent cardiological evaluation, echocardiogram, pulmonary function tests (PFT) both atby 3 and by 12 months after discharge. Chest CT was performed by 12 months after discharge and chest CT. Specifically, the magnitude of pulmonary involvement between baseline and follow-up was considered the primary endpoint of this study. Secondary endpoints of the study were results of respiratory function testing, echocardiographic parametersparameters, and persistence of symptoms.

Conditions

• Pulmonary Fibrosis
• COVID-19

Interventions

Type	Name	Description
RADIATION	Computed tomography	Follow-up computed tomography at 3-6 months and 12 months

Timeline

• Start date: 2020-03-01
• Primary completion: 2022-03-01
• Completion: 2024-05-16
• First posted: 2024-05-21
• Last updated: 2024-05-21

Locations

1 site across 1 country: Italy