NCT06422572

Tissue Kallikrein Protect Against Ischemic Stroke

The Role of Tissue Kallikrein - Bradykinin System Targeting the Protection of Neurovascular Units in Ischemic Areas of Stroke

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8,602 (actual)
• Sponsor: Qin Zhang · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

The results of previous studies were used to assess the causal association between TK levels and stroke occurrence at 5 and 12 years of follow-up, respectively.

Detailed description

Analyze the data of a 5-year follow-up on 2115 control individuals from the case-control study of the previous research. We completed the 5-year follow-up on this group in 2016 (whether they had a stroke, whether they are alive, and the cause of death). Conduct a 12-year follow-up on 6487 community individuals from the previous study (whether they had a stroke within 12 years, whether they are alive, and the cause of death). We collaborated with the hospital platform's computer center to conduct follow-up through AI questionnaire surveys, followed by supplementing AI questionnaire data with telephone questionnaire surveys for those lost to follow-up. Utilize R language R Studio 4.11 for statistical analysis and plotting. Evaluate the distribution of TK levels in the control group and its relationship with the 10-year predicted risk of stroke and the predictive role for stroke events within 5 years. Evaluate the distribution of TK levels in the community group and its relationship with the 10-year predicted risk of stroke and the predictive role for stroke events within 12 years.

Conditions

• Stroke, Ischemic

Interventions

Type	Name	Description
OTHER	No Intervention	No Intervention

Timeline

• Start date: 2023-05-01
• Primary completion: 2023-12-30
• Completion: 2023-12-30
• First posted: 2024-05-21
• Last updated: 2024-05-21

Locations

1 site across 1 country: China