Trials / Unknown
UnknownNCT06421116
Validation of a Preclinical Model Based on Patient-derived Organoids for the Study of the Gut-joint Axis in Spondyloarthritis
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (estimated)
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- —
Summary
This project aims to develop and validate a model of human organoids derived from patients with Spondyloarthritis, focusing on synovial and intestinal tissues as targets of the gut-joint axis. The tissue marker profile of patient-derived organoids studied by gene expression, immunohistochemistry, and cytokine production profile will be compared with that of controls in order to test for the presence of specific biomarkers.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Synovial ultrasound-guided biopsy Intestinal biopsy | Patients will undergo biopsies if needed for standard-of-care follow-up and after clinical indication. |
Timeline
- Start date
- 2024-03-07
- Primary completion
- 2024-12-31
- Completion
- 2025-12-31
- First posted
- 2024-05-20
- Last updated
- 2024-05-20
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06421116. Inclusion in this directory is not an endorsement.