NCT06420310

Pesticides and Parkinson´s Disease

Prevalence of Preclinical and Prodromal Parkinson´s Disease in Subjects Exposed to Pesticides

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 260 (estimated)
• Sponsor: Hospital Universitario de Burgos · Academic / Other
• Sex: All
• Age: 45 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms.

Detailed description

Within different risk factors, pesticide exposure increases the risk of developing Parkinson's disease (PD) through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunction.We will conduct a cross-sectional prevalence study with cases (exposed to pesticides) and controls (not exposed to pesticides), randomly selecting 130 individuals in each group. Pesticide exposure will be determined through questionnaires.We will study the prevalence of preclinical and prodromal PD based on pesticide exposure, stratified by age and gender in the exposed, and non-exposed groups. Preclinical and prodromal PD will be assessed using: biological biomarkers and prodromal PD signs. Multivariate analyses will be employed to determine the risk of presenting early PD, adjusting for different clinical covariates. The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure.

Conditions

• Pesticide-Induced Parkinsonism

Interventions

Type	Name	Description
OTHER	exposure to pesticides	based on work exposures to pesticides

Timeline

• Start date: 2024-04-01
• Primary completion: 2028-09-30
• Completion: 2028-12-30
• First posted: 2024-05-20
• Last updated: 2024-05-20

Locations

1 site across 1 country: Spain