NCT06419686

The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals

The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The study is a randomised, double-blinded, placebo-controlled, crossover study enrolling 10 healthy male participants. Each participant will undergo four separate study days in randomised order. Each study day encompasses a continous 90-minute i.v. infusion with either placebo, glucose-dependent insulinotropic polypeptide (GIP), alanine or GIP + alanine. The primary objective of the study is to find out whether intravenous administration of the naturally occuring gut hormone GIP and the amino acid alanine, separately and combined, results in additive or synergistic glucagonotropic effects during euglycaemic conditions in healthy participants. Secondary objectives are to disclose the effect of the abovementioned interventions on insulin secretion and circulating levels of total and individual amino acids.

Conditions

• Effect of iv Administration of GIP and Alanine

Interventions

Type	Name	Description
OTHER	Placebo (saline)	Intravenous saline during experimental days.
DRUG	GIP	Intravenous GIP administration during experimental days.
DRUG	Alanine	Intravenous alanine administration during experimental days.
DRUG	GIP + alanine	Intravenous administration of GIP and alanine during experimental days.

Timeline

• Start date: 2024-01-01
• Primary completion: 2024-05-01
• Completion: 2024-07-01
• First posted: 2024-05-17
• Last updated: 2024-05-17

Locations

1 site across 1 country: Denmark