NCT06415383

The Effects of Vitamin B6 Supplementation on Pain Thresholds and Tolerance

Testing the Effects of High-dose Vitamin B6 Supplements on Pain Thresholds and Tolerance in Healthy Adults

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: University of Reading · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This clinical trial aims to explore the effect of Vitamin B6 supplementation on pain thresholds and tolerance in healthy adults using thermal and electrical stimulation. Researchers will compare a placebo group to high-dose Vitamin-B6 to see if vitamin B6 increases pain thresholds and tolerance.

Detailed description

The main questions it aims to answer are: * How does vitamin B6 affect pain thresholds and tolerance following a single 100mg dose? * How does vitamin B6 affect pain thresholds following daily supplementation for up to a month? * Does vitamin B6 supplementation affect measures related to the experience of pain, such as state anxiety, sleep, diet, and mood at different time points

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Vitamin B6 100 MG	Vitamin B6 in for the form of pyridoxal phosphate (PLP)
OTHER	Placebo	Placebo tablet containing microcrystalline cellulose

Timeline

• Start date: 2024-05-30
• Primary completion: 2025-03-01
• Completion: 2025-06-30
• First posted: 2024-05-16
• Last updated: 2026-03-11

Locations

1 site across 1 country: United Kingdom