NCT06413212

Exploratory Study of Precise Therapy for Advanced Tumor Patients With Malignant Hydrothorax or Ascites by Using PTC Drug Sensitivity Testing

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 55 (estimated)
• Sponsor: Liu Huang · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To explore the consistency between result of PTC drug screening tests and actual clinical outcome for patients with advanced malignancy.

Detailed description

This study is anticipated to enroll 55 patients with advanced malignancy, and fresh malignant effusion samples collected from patients would be detected by PTC drug screening. In addition, patients would receive 2 cycles of personal therapy based on results of screening tests. By combining PTC drug sensitivity results with patient's treatment process and clinical feedback, researchers may evaluate the sensitiveness and specificity of PTC drug screening technique in predicting clinical outcome for advanced malignancy patients.

Conditions

• Lung Cancer
• Breast Cancer
• Gastric Cancer
• Colorectal Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.	Fresh malignant effusion samples were collected from advanced malignancy patients for PTC drug sensitivity testing, then assess the accuracy of this diagnostic test by combination and analysis with final clinical outcome.

Timeline

• Start date: 2023-08-04
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2024-05-14
• Last updated: 2025-06-04

Locations

1 site across 1 country: China