NCT06412705

Vit D and Post-extractive Bone Turnover

The Effect of Vit D on Post-extraction Site Bone Remodeling and Regeneration After 4 Months: A Prospective Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aims of the study was to correlate the extent of the dimensional alveolar bone changes after tooth extraction and contextual guided bone regeneration with serum vit D levels in 14 patients. Moreover, at 4 months, a small bone sample was collected in order to correlate histological and immunohistochemical parameters of bone with vit D serum levels.

Detailed description

The study included 14 patients requiring tooth extraction and subsequent post-extraction bone regeneration with heterologous graft material of porcine origin. Four months after extraction, dental implants were placed, and insertion torque values (ITV) and implant stability quotients (ISQ) were recorded. During implant placement, a small bone sample was collected for histological analysis. The aim of the study was to analyze the correlation between serum vitamin D levels and post-extraction bone volume contraction, collagen type I (Col1A1), osteocalcin, osteopontin, runt-related transcription factor 2 (Runx2), ITV, ISQ, Newly Formed Bone Tissue (NFBT).

Conditions

• Vitamin D Deficiency
• Alveolar Bone Loss
• Alveolar Bone Resorption

Interventions

Type	Name	Description
PROCEDURE	Tooth extraction, guided bone regeneration and dental implant	The arm received tooth extraction and contextual guided bone regeneration. After 4 months, a dental implant was inserted.

Timeline

• Start date: 2023-10-02
• Primary completion: 2024-04-30
• Completion: 2024-04-30
• First posted: 2024-05-14
• Last updated: 2024-05-14

Locations

1 site across 1 country: Italy