NCT06409624

Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension

Association Between Biomarkers and Kidney Function Decline in Patients With Pulmonary Hypertension

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 350 (estimated)
• Sponsor: University of Giessen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).

Detailed description

PH is a severe, progressive disease associated with right ventricular dysfunction, right-sided heart failure (HF) and death. Kidney disease is present in approximately 35% of patients with PH, and its presence is associated with an enhanced risk for adverse outcomes, with the risk increasing incrementally with declining kidney function. Poor right ventricular function may increase venous congestion, alter ventricular interdependence, decrease effective cardiac output and activate the renin-angiotensin- aldosterone system, thereby aggravating kidney disease. There is a crucial need to better understand the pathophysiological mechanisms linking the failing right heart and the kidney. To date, diagnostic and prognostic biomarkers of kidney disease in PH are lacking. The objective of this study is to examine the association between urinary and plasma biomarkers and change in eGFR among patients with PH.

Conditions

• Pulmonary Hypertension
• Chronic Kidney Disease

Interventions

Type	Name	Description
OTHER	No intervention is planned as part of the study	No intervention is planned as part of the study

Timeline

• Start date: 2024-05-31
• Primary completion: 2026-12-31
• Completion: 2027-07-01
• First posted: 2024-05-10
• Last updated: 2025-10-06

Locations

1 site across 1 country: Germany