NCT06405256

Magnetic Resonance Imaging-guided Adaptive Radiotherapy for Large Brain Metastases

Displacement and Deformation Analysis of Adaptive Radiotherapy Based on MR-Linac for Large Brain Metastases

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study is an ambispective cohort study to evaluate the displacement and deformation of large brain metastases (BM) treated with magnetic resonance imaging-guided adaptive radiotherapy (MRIgART)

Detailed description

All patients had a pathologically confirmed malignant cancer and were diagnosed with brain metastases (BM) by enhanced magnetic resonance imaging (MRI) with BM volume of 2cm and above. All patients received Unity MR-linac adaptive radiotherapy. Gross tumor volume (GTV) and organs at risk (OARs) were re-delineated for every image set and analyzed for displacement and deformation.

Conditions

• Brain Metastases

Interventions

Type	Name	Description
RADIATION	magnetic resonance imaging-guided adaptive radiotherapy	Stereotactic Radiotherapy (with the prescribed dose of PTV 52-52.5 Gy, 13-15 fractions and Boost (if any) 60Gy, 15 fractions)

Timeline

• Start date: 2020-01-03
• Primary completion: 2025-03-18
• Completion: 2025-03-18
• First posted: 2024-05-08
• Last updated: 2024-05-08

Locations

1 site across 1 country: China