NCT06403176

Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

Arteriovenous Plasma Multiomics and Inflammatory Factors in Patients With Disorders of Consciousness

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: First Affiliated Hospital of Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Detailed description

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis. Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.

Conditions

• Disorders of Consciousness
• Transient Ischemic Attack

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2022-05-01
• Primary completion: 2024-03-30
• Completion: 2024-04-30
• First posted: 2024-05-07
• Last updated: 2024-05-07

Locations

1 site across 1 country: China