NCT06401928

Electrical Brain Stimulation for Treatment of Secondary Symptoms in Multiple Sclerosis

Electrical Brain Stimulation for Improving Mental Health and Cognitive Functioning in Patients With Multiple Sclerosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: The National Brain Mapping Laboratory (NBML) · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Multiple Sclerosis (MS) is an autoimmune disease associated with physical disability, psychological impairment, and cognitive dysfunction. As a result, the disease burden is high, and treatment options are limited. In this randomized, double-blind study, the investigators planned to use repeated electrical stimulation and assess mental health-related variables (e.g., quality of life, sleep, psychological distress) and cognitive dysfunction in patients with MS.

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
DEVICE	transcranial direct current stimulation	Patients will receive 10 sessions of either 1.5 mA electrical stimulation for 20 minutes each day over 10 consecutive days.
DEVICE	transcranial direct current stimulation combined with cognitive training	Patients will receive 10 sessions of 20 minutes of 1.5 mA electrical stimulation on 10 consecutive days. Each session is followed by 30 minutes cognitive training in which patients conduct several computerized cognitive tests.
DEVICE	transcranial direct current stimulation	Patients will receive 10 sessions of sham (placebo) electrical stimulation for 20 minutes each day over 10 consecutive days.

Timeline

• Start date: 2023-02-28
• Primary completion: 2023-12-15
• Completion: 2024-01-31
• First posted: 2024-05-07
• Last updated: 2026-03-17

Locations

1 site across 1 country: Iran