Trials / Active Not Recruiting
Active Not RecruitingNCT06400082
Topical Insulin for Postoperative Wound Healing
Investigating the Impact of Topical Insulin on Postoperative Wound Healing in Diabetic and Non-Diabetic Patients: A Randomized Controlled Trial
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 74 (actual)
- Sponsor
- Cairo University · Academic / Other
- Sex
- All
- Age
- 40 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
This study aimed to investigate the potential effect of applying topical insulin therapy on the management and healing of postoperative wounds in patients known with type 2 diabetes mellitus (T2DM) and in a parallel group without diabetes. Investigators also studied the effect of topical insulin therapy on the expression of e-cadherin and Ki67, as markers for cellular proliferation and wound repair. The levels of IL-6 and the H2O2-induced DNA damage product, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were assessed as markers for inflammation and oxidative stress. Finally, histomorphological assessment of skin biopsies was also carried out.
Detailed description
The study participants will be recruited from general surgery department ,all patients with elective surgical procedure who will be admitted at the department for at least one week as it is the minimal duration of postoperative wound healing and the study will be conducted according to the regulations of ethical committee of clinical studies in the Faculty of Medicine, Cairo University
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Insulin | Insulin is applied as a topical dressing for postoperative wounds and compared to the conventional povidone iodine treatment |
| DRUG | Povidone-Iodine | Insulin is applied as a topical dressing for postoperative wounds and compared to the conventional povidone iodine treatment |
Timeline
- Start date
- 2023-04-16
- Primary completion
- 2024-10-01
- Completion
- 2024-12-10
- First posted
- 2024-05-06
- Last updated
- 2024-08-21
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT06400082. Inclusion in this directory is not an endorsement.